Pedosphere 30(5): 577--588, 2020
ISSN 1002-0160/CN 32-1315/P
©2020 Soil Science Society of China
Published by Elsevier B.V. and Science Press
Diversity and versatile functions of metallothioneins produced by plants: A review
SAEED-UR-RAHMAN1, Muhammad KHALID2, Nan HUI2, Sadaf-Ilyas KAYANI1, Kexuan TANG1
1Joint International Research Laboratory of Metabolic & Developmental Sciences, Key Laboratory of Urban Agriculture (South) of Ministry of Agriculture, Plant Biotechnology Research Center, Fudan-SJTU-Nottingham Plant Biotechnology R&D Center, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240 (China)
2Key Laboratory of Urban Agriculture, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240 (China)
ABSTRACT
      Metal ions are essential for plant growth and development, but in excess, these compounds can become highly toxic. Plants have adopted numerous ways to maintain metal homeostasis while mitigating adverse effects of excess metal ions, including phytochelatin and the metal-chelating proteins metallothioneins (MTs). A family of cysteine (Cys)-rich, intracellular, and low-molecular-weight (4-8 kDa) MTs are proteins found in nearly all phyla including plants, animals, and fungi, and they have the potential to scavenge reactive oxygen species and detoxify toxic metals including copper, cadmium, and zinc. Based on their Cys numbers and residues, MTs have been categorized into three major classes. Class I MTs, which have highly conserved Cys residues, are found in animals, while class Ⅱ MTs, with less conserved Cys residues, are present in plants and are classified further into four groups. Class Ⅲ MTs include phytochelatins, a group of enzymatically synthesized Cys-rich proteins. The MTs have been an area of interest for five decades with extensive studies, which have been facilitated by advancements in instrumental techniques, protein science, and molecular biology tools. Here, we reviewed current advances in our understanding of the regulation of MT biosynthesis, their expression, and their potential roles in the alleviation of abiotic stresses (i.e., drought, salinity, and oxidative stresses) and heavy metal detoxification and homeostasis.
Key Words:  abiotic stress,biosynthesis,gene expression,heavy metals,reactive oxygen species,enzyme regulation
Citation: Saeed-Ur-Rahman, Khalid M, Hui N, Kayani S I, Tang K X. 2020. Diversity and versatile functions of metallothioneins produced by plants:A review. Pedosphere. 30(5):577-588.
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