Pedosphere 29(3): 273--282, 2019
ISSN 1002-0160/CN 32-1315/P
©2019 Soil Science Society of China
Published by Elsevier B.V. and Science Press
Antibiotic Resistance Genes in the Human-Impacted Environment: A One Health Perspective
James M. TIEDJE1,2, WANG Fang1,2,3, Célia M. MANAIA4, Marko VIRTA5, SHENG Hongjie1,2, MA Liping6, ZHANG Tong6, Edward TOPP7
1Key Laboratory of Soil Environment and Pollution Remediation, Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008(China);
2Center for Microbial Ecology, Department of Plant, Soil and Microbial Sciences, Michigan State University, East Lansing MI 48824(USA);
3University of Chinese Academy of Sciences, Beijing 100049(China);
4Universidade Católica Portuguesa, CBQF-Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Porto 4200-374(Portugal);
5Department of Microbiology, University of Helsinki, Helsinki 00014(Finland);
6Environmental Biotechnology Lab, The University of Hong Kong, Hong Kong(China);
7London Research and Development Centre, Agriculture and Agri-Food Canada and University of Western Ontario, London ON N6G 0J3(Canada)
ABSTRACT
      Antibiotic resistance and its environmental component are gaining more attention as part of combating the growing healthcare crisis. The One Health framework, promulgated by many global health agencies, recognizes that antimicrobial resistance is a truly inter-domain problem in which human health, animal agriculture, and the environment are the core and interrelated components. This prospectus presents the status and issues relevant to the environmental component of antibiotic resistance, namely, the needs for advancing surveillance methodology:the environmental reservoirs and sources of resistance, namely, urban wastewater treatment plants, aquaculture production systems, soil receiving manure and biosolid, and the atmosphere which includes longer range dispersal. Recently, much work has been done describing antibiotic resistance genes in various environments; now quantitative, mechanistic, and hypothesis-driven studies are needed to identify practices that reduce real risks and maintain the effectiveness of our current antibiotics as long as possible. Advanced deployable detection methods for antibiotic resistance in diverse environmental samples are needed in order to provide the surveillance information to identify risks and define barriers that can reduce risks. Also needed are practices that reduce antibiotic use and thereby reduce selection for resistance, as well as practices that limit the dispersal of or destroy antibiotic-resistant bacteria or their resistance genes that are feasible for these varied environmental domains.
Key Words:  animal agriculture,antibiotic-resistant bacteria,antimicrobial resistance,aquaculture,human health,One Health framework,soil contamination,wastewater and sludge
Citation: Tiedje J M, Wang F, Manaia C M, Virta M, Sheng H J, Ma L P, Zhang T, Topp E. 2019. Antibiotic resistance genes in the human-impacted environment:A One Health perspective. Pedosphere. 29(3):273-282.
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